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Ritmo Circadiano, Carcinogenesis y Trabajo Nocturno

Ritmo Circadiano, Carcinogenesis y Trabajo Nocturno

  1. Médico Residente en Terapia Intensiva
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    Ritmo Circadiano, Carcinogenesis y Trabajo Nocturno

    Graveyard shift work linked to cancer
    By MARIA CHENG, AP Medical Writer Thu Nov 29, 6:56 PM ET

    LONDON - Like UV rays and diesel exhaust fumes, working the graveyard shift will soon be listed as a "probable" cause of cancer. It is a surprising step validating a concept once considered wacky. And it is based on research that finds higher rates of breast and prostate cancer among women and men whose work day starts after dark.

    Next month, the International Agency for Research on Cancer, the cancer arm of the World Health Organization, will add overnight shift work as a probable carcinogen. The American Cancer Society says it will likely follow. Up to now, the U.S. organization has considered the work-cancer link to be "uncertain, controversial or unproven."

    The higher cancer rates don't prove working overnight can cause cancer. There may be other factors common among graveyard shift workers that raise their risk for cancer.

    However, scientists suspect that overnight work is dangerous because it disrupts the circadian rhythm, the body's biological clock. The hormone melatonin, which can suppress tumor development, is normally produced at night.

    If the graveyard shift theory eventually proves correct, millions of people worldwide could be affected. Experts estimate that nearly 20 percent of the working population in developed countries work night shifts.

    Among the first to spot the night shift-cancer connection was Richard Stevens, a cancer epidemiologist and professor at the University of Connecticut Health Center. In 1987, Stevens published a paper suggesting a link between light at night and breast cancer.

    Back then, he was trying to figure out why breast cancer incidence suddenly shot up starting in the 1930s in industrialized societies, where nighttime work was considered a hallmark of progress. Most scientists were bewildered by his proposal.

    But in recent years, several studies have found that women working at night over many years were indeed more prone to breast cancer. Also, animals that have their light-dark schedules switched develop more cancerous tumors and die earlier.

    Some research also suggests that men working at night may have a higher rate of prostate cancer.

    Because these studies mostly focused on nurses and airline crews, bigger studies in different populations are needed to confirm or disprove the findings.

    There are still plenty of skeptics. And to put the risk in perspective, the "probable carcinogen" tag means that the link between overnight work and cancer is merely plausible.

    Among the long list of agents that are listed as "known" carcinogens are alcoholic beverages and birth control pills. Such lists say nothing about exposure amount or length of time or how likely they are to cause cancer. The American Cancer Society Web site notes that carcinogens do not cause cancer at all times.

    Still, many doubters of the night shift link may be won over by the IARC's analysis to be published in the December issue of the journal Lancet Oncology.

    "The indications are positive," said Vincent Cogliano, who heads up the agency's carcinogen classifications unit. "There was enough of a pattern in people who do shift work to recognize that there's an increase in cancer, but we can't rule out the possibility of other factors."

    Scientists believe having lower melatonin levels can raise the risk of developing cancer. Light shuts down melatonin production, so people working in artificial light at night may have lower melatonin levels.

    Melatonin can be taken as a supplement, but experts don't recommend it long-term, since that could ruin the body's ability to produce it naturally.

    Sleep deprivation may be another factor in cancer risk. People who work at night are not usually able to completely reverse their day and night cycles.

    "Night shift people tend to be day shift people who are trying to stay awake at night," said Mark Rea, director of the Light Research Center at Rensselaer Polytechnic Institute in New York, who is not connected with the IARC analysis.

    Not getting enough sleep makes your immune system vulnerable to attack, and less able to fight off potentially cancerous cells.

    Confusing your body's natural rhythm can also lead to a breakdown of other essential tasks. "Timing is very important," Rea said. Certain processes like cell division and DNA repair happen at regular times.

    Even worse than working an overnight shift is flipping between daytime and overnight work.

    "The problem is re-setting your body's clock," said Aaron Blair, of the United States' National Cancer Institute, who chaired IARC's recent meeting on shift work. "If you worked at night and stayed on it, that would be less disruptive than constantly changing shifts."

    Anyone whose light and dark schedule is often disrupted — including frequent long-haul travelers or insomniacs — could theoretically face the same increased cancer risk, Stevens said.

    He advises workers to sleep in a darkened room once they get off work. "The balance between light and dark is very important for your body. Just get a dark night's sleep."

    Meanwhile, scientists are trying to come up with ways to reduce night workers' cancer risk. And some companies are experimenting with different lighting, seeking a type that doesn't affect melatonin production.

    So far, the color that seems to have the least effect on melatonin is one that few people would enjoy working under: red.

    Graveyard shift work linked to cancer - Yahoo! News
    Prospective Cohort Study of the Risk of Prostate Cancer among Rotating-Shift Workers: Findings from the Japan Collaborative Cohort Study
    Tatsuhiko Kubo1,2, Kotaro Ozasa3, Kazuya Mikami4, Kenji Wakai5, Yoshihisa Fujino6, Yoshiyuki Watanabe3, Tsuneharu Miki4, Masahiro Nakao7, Kyohei Hayashi3, Koji Suzuki8, Mitsuru Mori9, Masakazu Washio9, Fumio Sakauchi9, Yoshinori Ito10, Takesumi Yoshimura11 and Akiko Tamakoshi10

    Abstract
    Shift workers have been reported to have an increased risk of some cancers. However, the risk of prostate cancer in shift workers is not known to have been examined previously. This study prospectively examined the association between shift work and risk of prostate cancer incidence among 14,052 working men in Japan enrolled in a large-scale prospective cohort. A baseline survey was conducted between 1988 and 1990. Subjects were asked to indicate the most regular work schedule they had undertaken previously: day work, rotating-shift work, or fixed-night work. During 111,974 person-years, 31 cases of prostate cancer were recorded. The Cox proportional hazards model was used to estimate the risk, with adjustments for age, family history of prostate cancer, study area surveyed, body mass index, smoking, alcohol drinking, job type, physical activity at work, workplace, perceived stress, educational level, and marriage status. Compared with day workers, rotating-shift workers were significantly at risk for prostate cancer (relative risk = 3.0, 95% confidence interval: 1.2, 7.7), whereas fixed-night work was associated with a small and nonsignificant increase in risk. This report is the first known to reveal a significant relation between rotating-shift work and prostate cancer.

    Prospective Cohort Study of the Risk of Prostate Cancer among Rotating-Shift Workers: Findings from the Japan Collaborative Cohort Study -- Kubo et al. 164 (6): 549 -- American Journal of Epidemiology
    Que joda. Eso de las guardias de 24 horas encima nos predispone a sufrir cancer de prostata. Juaz.


    Life does not cease to be funny when people die any more than it ceases to be serious when people laugh. -George Bernard Shaw
  2. Médico (no especialista)
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    Citar Originalmente publicado por Tincho Ver post
    Que joda. Eso de las guardias de 24 horas encima nos predispone a sufrir cancer de prostata. Juaz.
    De eso zafo...(?)

    Saludos!

    ¤ Que toda la vida es un sueño, y los sueños, sueños son... ¤




  3. 646
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    Una buena excusa para pedir un aumento para todos aquellos que laburen a la noche.
  4. Avatar de Titi
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    Mientras leia el art me acordaba que Cardinali habia dicho en un congreso que se daban suplementos de melatonina a personas con problemas para dormir... pero despues dice que puede llegar a suprimir la produccion endogena en ttos cronicos.

    Igualmente, como el problema mayor son las personas que cambian sus horarios de trabajo (como pueden ser las guardias), en ese caso no se podria dar la melatonina cuando se necesite?

    El resto de las personas que tienen su horario laboral a la noche, y lo mantienen en el tiempo, no se si tendran problemas con su ritmo circadiano, siempre y cuando duerman a oscuras, etc.

    Por lo menos se esta tratando de hacer algo con este tema... aunque te regalo trabajar toda la noche bajo luces rojas. No se uds, pero a mi me pondria nerviosisisma.

    Interesante, Tincho.
  5. Médico Residente en Terapia Intensiva
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    aunque te regalo trabajar toda la noche bajo luces rojas.
    No, no regalarias nada, cobrarias al fin y al cabo. xD

    Solo se puede ser puta o fotografo a este paso.

    En todo caso, voy a buscar mas sobre esto en algun momento en el futuro. Y mientras tanto, los medicos seguimos agregandole insalubridad a nuestra profesion... como si con lo que ya teniamos no alcanzaba. xD


    Life does not cease to be funny when people die any more than it ceases to be serious when people laugh. -George Bernard Shaw
  6. Avatar de Dengue
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    Sale listita manciana de cosas que hacen insalubre a la medicina???

    :B

    Con todas las justificaciones médicas y científicas que haya a mano de porqué es tan riesgosa. Y con eso vamos a hacer un reclamo para un aumento de sueldo pa' lo' medico'... wiiii !!!!!!



    Pasado mi momento de ilusa total vuelvo con mis amiga Citrulina... :B

    PD: le voy a decir a la gila de mi hermana que puede hacer las maquetas de día... sino, hay papa... :S

    Laws may make some types of works and inventions ineligible for monopoly; such works immediately enter the public domain upon publication. Many kinds of mental creations, are never covered by copyright.
  7. Avatar de Titi
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    Citar Originalmente publicado por Tincho Ver post
    No, no regalarias nada, cobrarias al fin y al cabo. xD
    Es verdad. Bueno, hay que verle el lado positivo a las cosas... el vaso medio lleno.
  8. Avatar de Julietitaa
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    Ah, ok. Además de vivir como el culo por estar acostumbrada a estudiar y prácticamente vivir de noche, encima me voy a morir de cancer?!

    Pero andate a la puta que te parió, mirá!
    Ya se, ya se, es horrible este estilo de vida. Pero no puedo de un día para el otro dormirme a las 12 de la noche. Ahora es la 1:20 y tengo bocha que leer. Que hago, me voy a dormir? Mah...


    Be kind to me, or treat me mean,
    I'll make the most of it, I'm an extraordinary machine.
  9. Médico Residente en Terapia Intensiva
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    Que hago, me voy a dormir?
    Anda si queres, pero sabe que CAUSA CANCER.



    Life does not cease to be funny when people die any more than it ceases to be serious when people laugh. -George Bernard Shaw
  10. Avatar de Julietitaa
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    Citar Originalmente publicado por Tincho Ver post
    Anda si queres, pero sabe que CAUSA CANCER.

    Che GILAZO eran la 1:18, si me iba a dormir en ese momento evitaba el cáncer. Y no lo hice, y hace mucho que no lo hago, y hoy particularmente me voy a zambullir en un tumor, porque rindo mañana y... capaz que duermo eh...!


    Be kind to me, or treat me mean,
    I'll make the most of it, I'm an extraordinary machine.
  11. Avatar de starckar
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    Tincho, acordate del otro thread... prácticamente somos putas. Yo no le veo la novedad a esto, es sabido que te morís antes, por lo menos ahora sabemos la causa. Cada disgusto te acorta 5 bases los telómeros.... QUIERO MIS TELÓMEROS DE VUELTA CARRERA HIJA DE P
  12. Médico Residente en Terapia Intensiva
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    Citar Originalmente publicado por starckar Ver post
    Tincho, acordate del otro thread... prácticamente somos putas. Yo no le veo la novedad a esto, es sabido que te morís antes, por lo menos ahora sabemos la causa. Cada disgusto te acorta 5 bases los telómeros.... QUIERO MIS TELÓMEROS DE VUELTA CARRERA HIJA DE P
    Bueh, en ese caso, pongamonos la lucecita roja, que de noche por lo menos parece mas beneficiosa y menos carcinogenica que la luz blanca.


    Life does not cease to be funny when people die any more than it ceases to be serious when people laugh. -George Bernard Shaw

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