Effect of Cyclosporine on Reperfusion Injury in Acute MI - Mancia.org | Foro de Salud y Medicina para estudiantes y medicos

Tincho · 30-jul-2008, 08:00

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

Christophe Piot, M.D., Ph.D., Pierre Croisille, M.D., Patrick Staat, M.D., Hélène Thibault, M.D., Gilles Rioufol, M.D., Ph.D., Nathan Mewton, M.D., Rachid Elbelghiti, M.D., Thien Tri Cung, M.D., Eric Bonnefoy, M.D., Ph.D., Denis Angoulvant, M.D., Christophe Macia, M.D., Franck Raczka, M.D., Catherine Sportouch, M.D., Gerald Gahide, M.D., Gérard Finet, M.D., Ph.D., Xavier André-Fouët, M.D., Didier Revel, M.D., Ph.D., Gilbert Kirkorian, M.D., Ph.D., Jean-Pierre Monassier, M.D., Geneviève Derumeaux, M.D., Ph.D., and Michel Ovize, M.D., Ph.D.

ABSTRACT
Background Experimental evidence suggests that cyclosporine, which inhibits the opening of mitochondrial permeability-transition pores, attenuates lethal myocardial injury that occurs at the time of reperfusion. In this pilot trial, we sought to determine whether the administration of cyclosporine at the time of percutaneous coronary intervention (PCI) would limit the size of the infarct during acute myocardial infarction.
Methods We randomly assigned 58 patients who presented with acute ST-elevation myocardial infarction to receive either an intravenous bolus of 2.5 mg of cyclosporine per kilogram of body weight (cyclosporine group) or normal saline (control group) immediately before undergoing PCI. Infarct size was assessed in all patients by measuring the release of creatine kinase and troponin I and in a subgroup of 27 patients by performing magnetic resonance imaging (MRI) on day 5 after infarction.
Results The cyclosporine and control groups were similar with respect to ischemia time, the size of the area at risk, and the ejection fraction before PCI. The release of creatine kinase was significantly reduced in the cyclosporine group as compared with the control group (P=0.04). The release of troponin I was not significantly reduced (P=0.15). On day 5, the absolute mass of the area of hyperenhancement (i.e., infarcted tissue) on MRI was significantly reduced in the cyclosporine group as compared with the control group, with a median of 37 g (interquartile range, 21 to 51) versus 46 g (interquartile range, 20 to 65; P=0.04). No adverse effects of cyclosporine administration were detected.
Conclusions In our small, pilot trial, administration of cyclosporine at the time of reperfusion was associated with a smaller infarct by some measures than that seen with placebo. These data are preliminary and require confirmation in a larger clinical trial.

NEJM -- Sign In

Solo puedo decir "wow".

muñoz santiago · 04-ago-2008, 11:17

Es una masa, pero como habran sacado que tiene ese efecto en la mitoconndria?

Yo tenia todas las fichas en la inmunomodulacion pero por otros metodos,ustedes sabian que hacia eso en los poros?

Nacho.tk · 05-ago-2008, 01:26

Lo lei en su momento y en vez de decir "wow" pensé "mierda! como no se me ocurrió a mi" jajaja

Si se fijan las citas, lo de la mitocondria y la ciclosporina es de hace mil años (eso sí que me sorprendió).
Que dejen de hacer cosas raras de investigación en cardio o para cuando llegue yo ya va a "estar todo dicho"

saludos
nacho
pd: Ojo que se viene la anakirna para el post IM

Tincho · 05-ago-2008, 06:48

La anawtf?

Y si, yo pense que seria algo asi como efecto inmunomodulador en la injuria por reperfusion, parecido pero no.

30-jul-2008, 08:00	#1 (permalink)
Tincho Manciano Bambi Registrado: enero-2007 País: Argentina Localización: Acassuso Universidad: Universidad de Wildstone Ocupación: Traducción Posts: 3,230 Agradecimientos realizados: 106 Agradecimientos recibidos: 148 en 89 posts	Effect of Cyclosporine on Reperfusion Injury in Acute MI Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction Christophe Piot, M.D., Ph.D., Pierre Croisille, M.D., Patrick Staat, M.D., Hélène Thibault, M.D., Gilles Rioufol, M.D., Ph.D., Nathan Mewton, M.D., Rachid Elbelghiti, M.D., Thien Tri Cung, M.D., Eric Bonnefoy, M.D., Ph.D., Denis Angoulvant, M.D., Christophe Macia, M.D., Franck Raczka, M.D., Catherine Sportouch, M.D., Gerald Gahide, M.D., Gérard Finet, M.D., Ph.D., Xavier André-Fouët, M.D., Didier Revel, M.D., Ph.D., Gilbert Kirkorian, M.D., Ph.D., Jean-Pierre Monassier, M.D., Geneviève Derumeaux, M.D., Ph.D., and Michel Ovize, M.D., Ph.D. ABSTRACT Background Experimental evidence suggests that cyclosporine, which inhibits the opening of mitochondrial permeability-transition pores, attenuates lethal myocardial injury that occurs at the time of reperfusion. In this pilot trial, we sought to determine whether the administration of cyclosporine at the time of percutaneous coronary intervention (PCI) would limit the size of the infarct during acute myocardial infarction. Methods We randomly assigned 58 patients who presented with acute ST-elevation myocardial infarction to receive either an intravenous bolus of 2.5 mg of cyclosporine per kilogram of body weight (cyclosporine group) or normal saline (control group) immediately before undergoing PCI. Infarct size was assessed in all patients by measuring the release of creatine kinase and troponin I and in a subgroup of 27 patients by performing magnetic resonance imaging (MRI) on day 5 after infarction. Results The cyclosporine and control groups were similar with respect to ischemia time, the size of the area at risk, and the ejection fraction before PCI. The release of creatine kinase was significantly reduced in the cyclosporine group as compared with the control group (P=0.04). The release of troponin I was not significantly reduced (P=0.15). On day 5, the absolute mass of the area of hyperenhancement (i.e., infarcted tissue) on MRI was significantly reduced in the cyclosporine group as compared with the control group, with a median of 37 g (interquartile range, 21 to 51) versus 46 g (interquartile range, 20 to 65; P=0.04). No adverse effects of cyclosporine administration were detected. Conclusions In our small, pilot trial, administration of cyclosporine at the time of reperfusion was associated with a smaller infarct by some measures than that seen with placebo. These data are preliminary and require confirmation in a larger clinical trial. NEJM -- Sign In Solo puedo decir "wow". __________________ L'ennui est contrerevolutionaire Life does not cease to be funny when people die any more than it ceases to be serious when people laugh. -George Bernard Shaw Disclaimer: Si el presente mensaje le disgustó, ofendió o molestó de alguna manera, intencional o no intencional, lo invito cordialmente a ignorarme.

04-ago-2008, 11:17	#2 (permalink)
muñoz santiago Manciano Patch Adams Registrado: julio-2007 País: Argentina Localización: san martin Universidad: Universidad de Buenos Aires Ocupación: Estudiante de Medicina Posts: 498 Agradecimientos realizados: 10 Agradecimientos recibidos: 24 en 19 posts	Es una masa, pero como habran sacado que tiene ese efecto en la mitoconndria? Yo tenia todas las fichas en la inmunomodulacion pero por otros metodos,ustedes sabian que hacia eso en los poros? __________________

05-ago-2008, 06:48	#4 (permalink)
Tincho Manciano Bambi Registrado: enero-2007 País: Argentina Localización: Acassuso Universidad: Universidad de Wildstone Ocupación: Traducción Posts: 3,230 Agradecimientos realizados: 106 Agradecimientos recibidos: 148 en 89 posts	La anawtf? Y si, yo pense que seria algo asi como efecto inmunomodulador en la injuria por reperfusion, parecido pero no. __________________ L'ennui est contrerevolutionaire Life does not cease to be funny when people die any more than it ceases to be serious when people laugh. -George Bernard Shaw Disclaimer: Si el presente mensaje le disgustó, ofendió o molestó de alguna manera, intencional o no intencional, lo invito cordialmente a ignorarme.

05-ago-2008, 01:26	#3 (permalink)
Nacho.tk AECUBA Registrado: enero-2007 País: Argentina Localización: CABA Universidad: Universidad de Buenos Aires Ocupación: Estudiante de Medicina Posts: 1,167 Agradecimientos realizados: 19 Agradecimientos recibidos: 109 en 53 posts MVP Condecoraciones: 1	Lo lei en su momento y en vez de decir "wow" pensé "mierda! como no se me ocurrió a mi" jajaja Si se fijan las citas, lo de la mitocondria y la ciclosporina es de hace mil años (eso sí que me sorprendió). Que dejen de hacer cosas raras de investigación en cardio o para cuando llegue yo ya va a "estar todo dicho" saludos nacho pd: Ojo que se viene la anakirna para el post IM